The activation of distinct signaling pathways then induces their differentiation into specialized subsets of T lymphocytes, including T helper (Th) 1, Th2, Th9, Th17, Th22, Tmog (T cells that are specific for the autoantigen, myelin oligodendrocyte glycoprotein (MOG), found in multiple sclerosis), and Treg (regulatory T cells) cells, which then undergo expansion in the spleen. The gene discussed is MOG; the disease is multiple sclerosis.