In a murine model of experimental autoimmune encephalomyelitis (EAE), a moderate diet in vitamin D (1500 IU/kg food) decreased the severity of EAE, while high doses of cholecalciferol supplementation (75000 IU/kg food) enhance activation, proinflammatory differentiation of T cells, and phagocytic activity of peripheral myeloid antigen-presenting cells, characterized by an enhanced surface expression of MHC class II and costimulatory molecules CD40, CD80, and CD86 [42]. This evidence concerns the gene CD86 and experimental autoimmune encephalomyelitis.