CYP27B1 and vitamin D deficiency: Furthermore, to test our hypothesis, we were not able to evaluate the expression at the mRNA, protein level, and enzymatic activity of the vitamin D hydroxylase enzymes involved in the catabolism of calcidiol such as CYP24A1 and the calcitriol renal and extrarenal synthesis such as CYP27B1 in the kidney and leucocytes from SLE patients and HS with vitamin D deficiency.