IL10 and systemic lupus erythematosus: In a biphasic dose-dependent manner, high calcitriol concentrations stimulate the plasma cell development; when B cells are terminally differentiating, induce a high IL-10 production, B cell hyperactivity, and autoantibody production associated with high clinical disease activity in SLE [5, 11, 13], highlighting that vitamin D could be an immunomodulatory nutrient that plays a bimodal role during physiological and pathological events.