IGHE and allergic disease: Also, as previously mentioned, a possible biphasic effect of vitamin D on allergies has been described; vitamin D deficiency may be related to allergic reactions; however, it has been hypothesized that the vitamin D excess leads to an increased allergy risk with a Th2 response predominance and high production of specific IgE against the allergen by the B cells, resulting in an acute inflammatory response [44, 45], maybe modulated by the pattern of high calcitriol when the calcidiol deficiency is presented.