The RT-PCR assay revealed that compared with tumor-adjacent tissues and normal hepatic cells, HCC tissues and cells showed a great decrease in the expression of miR-10b-5p (p < 0.05) and an increase in the expression of EphA2 (p < 0.05), and the expression of miR-10b-5p was negatively related to that of EphA2 (r = −0.698, p < 0.05). This evidence concerns the gene EPHA2 and neoplasm.