ACHE and early-onset autosomal dominant Alzheimer disease: Clinical trials of the acetylcholinesterase inhibitor Donepezil, currently indicated for Alzheimer's disease were not promising in VaD, with the drug found to be much less effective in VaD than in Alzheimer's disease (5), with patients attaining small improvements in cognitive function, but no improvement in global functioning that helps day-to-day life.