Four weeks after MI, 75% of mice survived and exhibited severe LV remodeling, as manifested by a 100% incidence of LVA, a significantly increased LV volume, a markedly reduced LVEF, and significant upregulation of natriuretic peptide type A (Nppa) and natriuretic peptide type B (Nppb) gene expression (Figures 1C–G). This evidence concerns the gene NPPA and myocardial infarction.