MYBPC3 and hypertrophy: Of the South Asian (SA)-specific variants, a polymorphic 25-base pair (bp) deletion in intron 32 (Δ25bp) of MYBPC3 is present in 4–6% (26–28) of SA individuals and a risk allele for late-onset LV dysfunction, hypertrophy, and HF with multiple forms of cardiomyopathy, such as HCM with an odds ratio of ~7 (26, 29) (Figures 1A,B).