After adjusting for age, gender, hypertension, coronary heart disease, diabetes, hyperlipidemia, smoking and alcohol history, It was found ANGPT2 level > 833 pg/ml was independently associated with type A AAD (RR = 47.297, 95%CI 16.497-135.601, p < 0.001). The gene discussed is ANGPT2; the disease is hypertensive disorder.