Gypenosides (Gps), the main active compound in the herbaceous plant Gynostemma pentaphylla Makino, decrease the NLRP3 inflammasome activation in hearts from STZ + HFD-treated rats and exerts anti-inflammatory properties improving myocardial histological changes associated to DCM although there is a lack of cardiac functional data associated with the treatment (30). The gene discussed is NLRP3; the disease is familial dilated cardiomyopathy.