The inhibition of miR-223, a miRNA expressed in diabetes, downregulates the markers of inflammation (NLRP3), fibrosis (collagens I and III), and apoptosis (caspase-3 and Bax), attenuating the cardiac effects as well in the systolic function and ventricular remodeling of STZ-induced diabetes (24). This evidence concerns the gene NLRP3 and diabetes mellitus.