As mentioned above, FGF21 plays a role in inhibiting retinal neovascularization As a regulatory secretion mainly produced by the liver (Geng et al., 2020; Keuper et al., 2020), oxidative damage and chronic inflammation of NAFLD suppressed β-klotho and FGFR expression, leading to a compensatory increase in FGF21 synthesis and secretion (Tucker et al., 2019). This evidence concerns the gene FGF21 and metabolic dysfunction-associated steatotic liver disease.