In HCC, lncRNA epidermal growth factor receptor (EGFR) suppressed cytotoxic T lymphocyte (CTL) activity, stimulated regulatory T cell (Treg) differentiation, and accelerated HCC growth via blocking EGFR ubiquitination with c-CBL (Jiang et al., 2017). The gene discussed is EGFR; the disease is hepatocellular carcinoma.