Wang et al. (2020) have revealed that the lncRNA NNT-AS1 impaired CD4+ T-cell infiltration via activation of the TGF-β signaling pathway in HCC. Moreover, several studies have reported the remarkable role of an lncRNA risk model for survival prediction in HCC (Sun et al., 2019; Xu et al., 2021a; Zhou et al., 2021a), as well as including immune-related lncRNAs, which was capable of predicting the survival and therapeutic responses of HCC patients (Zhang et al., 2020; Wang et al., 2021a; Wu et al., 2021b; Xu et al., 2021b; Zhou et al., 2021b). This evidence concerns the gene CD4 and hepatocellular carcinoma.