M1 macrophages usually expressed MHC-II, CD68, CD80, and CD86 and had the effect of antitumor and pro-inflammation, while the M2 microphage in the tumor microenvironment could play a role in pro-tumor, immunosuppression, and anti-inflammation (Malfitano et al., 2020; Mantovani et al., 2021). This evidence concerns the gene CD80 and neoplasm.