Overexpression of MAP3K8 was found in several tumor types, including skin cancer, prostate cancer, breast cancer, squamous cell carcinoma, ovarian cancer, hepatocellular carcinoma, and colorectal cancer (Sourvinos et al., 1999; Jeong et al., 2011; Gruosso et al., 2015; Lee et al., 2015; Li et al., 2015; Pyo et al., 2018). This evidence concerns the gene MAP3K8 and hepatocellular carcinoma.