The expression of MAP3K8 was positively correlated with the enrichment of memory CD4+ T cells, effector memory CD4+ T cells, plasmacytoid dendritic cells, neutrophils, myeloid dendritic cells, mast cells, macrophages, M2 macrophage, and M1 macrophage in glioma. This evidence concerns the gene MAP3K8 and central nervous system cancer.