To test whether this was the case for GBM, we analyzed the expression profile of representative genes involved in the formation of the electron transport chain complexes: NADH: Ubiquinone Oxidoreductase Subunit A5 (NDUFA5 -complex I); Ubiquinol-Cytochrome C Reductase Binding Protein (UQCRB-complex III), Cytochrome C Oxidase Subunit 5A (COX5A-complex IV). The gene discussed is NDUFA5; the disease is glioblastoma.