HK2 and glioblastoma: Importantly, Niclou and colleagues have investigated the importance of glycolytic enzymes in GBM adaption and survival including HK2, ALDO, and PGAM1 in 5 patient-derived GBM stem-like cell lines and found that inhibition of these glycolytic genes pathway strongly affects GBM growth in patient-derived intracranial mouse models (Sanzey et al., 2015).