In our study, the methylation level of CRC and adenoma was statistically different in stool samples (Figures 2C,D); however, SDC2/TFPI2 did not differentiate CRC and adenoma well enough (Figure 3 and Table 4), which meant that the methylation pattern of adenoma was more similar to that of CRC. This evidence concerns the gene TFPI2 and colorectal carcinoma.