SDC2 and colorectal carcinoma: We firstly demonstrated that there was a subsite difference in colorectal methylation between TFPI2 and SDC2, and as high as 88.0% SDC2 hypomethylated CRC samples retrieved from TCGA were TFPI2 hypermethylated (Table 2), in agreement with the result from the MSP assays in stool samples (Table 3).