TFPI2 and colorectal carcinoma: The methylation level of 391 CRC tissues was significantly higher than that of 45 normal tissues, either for the SDC2 gene (0.479 ± 0.178 vs. 0.067 ± 0.018) or for the TFPI2 gene (0.558 ± 0.149 vs. 0.161 ± 0.078).