TFPI2 and adenoma: For adenoma vs. normal (Figure 3B; Table 4), the AUC value of SDC2/TFPI2-combined detection was 0.87 (95% CI: 0.81–0.92) with the specificity of 95.70% and sensitivity of 80.00%, while the AUC value of SDC2 detection was 0.64 (95% CI: 0.57–0.71) with the specificity of 99.30% and sensitivity of 44.20%.