Loss or downregulation of Nr4a3 (Log2FC = −5.87), Scd1 (Log2FC = −2.24), Chrna4 (Log2FC = −4.23), and Fabp5 (Log2FC = −3.82) increase glucose intolerance, insulin resistance, diet-induced fatty liver disease, and cholinergic anti-inflammatory pathways (30–32). The gene discussed is CHRNA4; the disease is Insulin resistance.