In the gene-level analyses, we first tested diet-level changes between groups and found that both WT and ChemR23 KO obese mice had dysregulated pathways related to insulin signaling, glucose intolerance, hepatic steatosis, and NAFLD compared to lean WT and ChemR23 KO controls. The gene discussed is CMKLR1; the disease is metabolic dysfunction-associated steatotic liver disease.