When comparing obese KO mice with lean KO mice, the obese KOs had upregulated differentially expressed exons largely contributing to pathways in NAFLD and oxidative phosphorylation, like in the gene-level analysis, but unlike the gene-level results PPAR signaling and complement/coagulation cascades were also upregulated in the exon-level results (Figure 3B). The gene discussed is PPARA; the disease is metabolic dysfunction-associated steatotic liver disease.