• ↓ ATN score, intrarenal hemorrhage, apoptosis; • ↓ KIM-1 and NGAL in urine; • ↑ RBF, total UO; • ↓ urinary protein, ↑ CrCl; • ↓ gene expression of TLR2 and 6, MyD88, NF-κB and HMGB1. The gene discussed is HMGB1; the disease is oculocutaneous albinism type 1.