Characterization of tumor cellular components at different times post-transplantation together with dynamic changes of the immunological context during progression showed that, as in patients, pre-invasive lesions were heavily infiltrated by granulocytes, macrophages, and regulatory T cells (Treg) cells that endured through progression, whereas helper CD4+ T and cytotoxic CD8+ T cells were excluded as the tumor progresses and degree of myeloid-derived suppressor cells (g-MDSC) and M2 macrophages increased (36). This evidence concerns the gene CD4 and neoplasm.