Furthermore, in naïve mouse models during infection (54), mapping by peptides and virus-like particles of structural (S, N, M, E) and selected ORFs (ORF3a, ORF6, ORF7a, ORF8, ORF9b, and ORF9c) showed a similar immunodominance of CD4+ T cell responses toward S, N, and ORF8-derived peptides. The gene discussed is CD4; the disease is infection.