Strikingly, two key TCRα motifs in the CDR3α region were detected across COVID-19 individuals, namely TRAV12-1/TRAJ43 CVVNXXXDMRF motif paired with different prominent TRBV genes, and TRAV12-2/TRAJ30 CAVNXDDKIIF paired with TRBV7-9, which is also found by Shomuradova et al. (62). This evidence concerns the gene TRAJ43 and COVID-19.