The low precursor frequency of A2/S269+CD8+ T cells can be explained, at least partially, by the skewed TCR repertoire, with common TRBV gene segments (TRBV2, TRBV7-9, and TRBV20-1), TRBJ (TRBJ2-2, TRBJ2-7), TRAV (TRAV12-1, TRAV12-2, TRAV14/DV4), and TRAJ (TRAJ43, TRAJ30) across different patients with COVID-19. Here, TRAV12-1 is linked to COVID-19.