Consistent with down-regulation of PPARα expression in chronic ischemic retinopathy [e.g., DM-induced retinopathy (10), oxygen-induced proliferative retinopathy (15)] and in other non-retinal organs injured by IR [e.g., heart (29), kidney (30), and intestine (31)], PPARα expression in the IR retina was decreased 24 h after modeling, indicating that PPARα was involved in the retinal pathological process of IR injury. The gene discussed is PPARA; the disease is retinal disorder.