Airway microbiome in COVID-19 samples were less diversifed. Certain microbiota were associated with CRP concentration 47.4% of COVID-19 samples revealed an increase of presence in opportunistic pathogens compared to 52% of non-COVID-19 samples. Increased abundance of Human infuenza virus, Respiratory syncytial viruses, Human alphaherpesvirus 1 and Candida albicans in COVID-19 patients compared to non-COVID-19 patients. The gene discussed is CRP; the disease is COVID-19.