Most readers, including YTHDC1, YTHDF3, HNRNPC, FMR1, LRPPRC, HNRNPA2B1, IGFBP3, and IGFBP1, tended to obtain an amplification of CNV, whereas all two erasers (FTO and ALKBH5) tended to obtain a depletion of CNV in bladder tumors. The gene discussed is IGFBP3; the disease is urinary bladder neoplasm.