However, some m6A regulators, including METTL3, RBM15B, YTHDF1, YTHDF2, and IGFBP3, were significantly overexpressed in bladder tumors, and some m6A regulators, including METTL14, METTL16, ZC3H13, and YTHDF3, were markedly downregulated in bladder tumors. This evidence concerns the gene METTL16 and urinary bladder neoplasm.