To decipher how MT1-MMP could modulate 3D COL1-induced apoptosis, shRNA strategy against MT1-MMP mRNA was used in the MDA-MB-231 basal-like breast carcinoma cell line, which displays a mesenchymal phenotype characterized by high expression of MT1-MMP and low level of DDR1 (Saby et al., 2019). The gene discussed is DDR1; the disease is breast carcinoma.