High CDKN2A expression levels were positively associated with memory activated CD4 T cells, CD8 T cells, activated NK cells, regulatory T cells (Tregs), activated dendritic cells, and follicular helper T cells and were negatively related to the resting immune cell levels of mast cells, M2 macrophages, and memory resting CD4 T cells in BRCA. Here, CD8A is linked to invasive breast carcinoma.