Here, we sought to determine the CDKN2A gene deletion status in 33 kinds of tumors, and through analysis of the CDKN2A gene and patient survival, correlations between clinical tumor stage, tumor mutation load, microsatellite correlation, the relationships between tumor microenvironment, immune cell infiltration, gene expression and enrichment of GSEA, the relationship between the CDKN2A gene and tumor progression was assessed. This evidence concerns the gene CDKN2A and neoplasm.