Palmitoylation mediated by the palmitoyltransferase zinc finger DHHC-Type palmitoyltransferase 3 (ZDHHC3) in the cytoplasmic domain of PD-L1 blocks its ubiquitination to stabilize PD-L1, thereby, suppressing PD-L1 degradation by lysosomes and PD-L1-mediated immune evasion in cancer (Yao et al., 2019). This evidence concerns the gene CD274 and cancer.