Sirtuin 2 (SIRT2) mediates the deacetylation of isocitrate dehydrogenase (NADP (+)) 1 (IDH1), thereby, promoting IDH1 activity and the production of α-ketoglutarate (α-KG), inhibiting liver metastasis of colon cancer and improving prognosis (Wang et al., 2020). The gene discussed is SIRT2; the disease is colonic neoplasm.