In several human cancers, signal transducer and activator of transcription 3 (STAT3) is palmitoylated by zinc finger DHHC-Type palmitoyltransferase 19 (ZDHHC19), a palmitoyl acyltransferase, at the SRC homology 2 (SH2) domain, which promotes its dimerization and transcriptional activation. This evidence concerns the gene STAT3 and cancer.