Peroxisome proliferator activated receptor alpha (PPARα), a nuclear receptor that regulates lipid homeostasis, inhibits DNA methyltransferase 1 (DNMT1)-mediated cyclin dependent kinase inhibitor 1A (CDKN1A) and PRMT6-mediated cyclin dependent kinase inhibitor 1b (CDKN1B) to promote colon cancer (Luo et al., 2019). Here, DNMT1 is linked to colonic neoplasm.