In the univariate analysis, lymph node metastasis was significantly associated with age (p = 0.078), tumor size (p = 0.003), ulceration (p = 0.002), submucosal invasion (p < 0.001), histology subtype (p < 0.001), lymphovascular invasion (p < 0.001), perineural invasion (p = 0.007), and HER2 positivity (p < 0.001). This evidence concerns the gene ERBB2 and neoplasm.