For example, DHX32 interacts with and stabilizes β-catenin to promote angiogenesis in colorectal cancer cells (Lin et al., 2017), the redox-sensitive enzyme SENP3 interacts with β-catenin and inhibits its proteasome-dependent degradation in vascular smooth muscle cells (Cai et al., 2021), and MRP4 sustains β-catenin signalling by binding to β-catenin and blocking its degradation in the receptive endometrium to facilitate IVF (Chen et al., 2019). The gene discussed is DHX32; the disease is colorectal cancer.