In HCC tissues, m6A methyltransferases WATP and KIAA1429 are related to prognosis (Chen et al., 2019b; Liu et al., 2020b), and METTL3, YTHDF2, ZC3H13 and ALKBH5 are considered independent prognostic factors for overall survival; of these, only METTL3 is an independent prognostic factor for recurrence-free survival (Li et al., 2019b; Liu et al., 2021). This evidence concerns the gene METTL3 and hepatocellular carcinoma.