The m6A “reader” IGF2BP1 plays an oncogenic role in HCC progression, but the decrease of lncRNA LIN28B-AS can deplete the expression of IGF2BP1-dependent mRNAs, such as IGF2 and Myc, thereby inhibiting HCC cell proliferation, migration, and invasion (Zhang et al., 2020c). Here, IGF2 is linked to hepatocellular carcinoma.