As an important demethylase, FTO has been identified to play an oncogenic role in NSCLC, ovarian cancer, and acute myeloid leukemia, associating with cancer cell proliferation, cancer stem cell maintenance and other malignant characteristics (Huang et al., 2020a; Huang et al., 2019; Li et al., 2019a). The gene discussed is MBD2; the disease is cancer.