METTL3 and cancer: METTL3-mediated methylation can also enhance the stability of lncRNA FAM225A, which regulates the expression of ITGB3 by binding to miR-590-3p and miR-1275 as ceRNA, and thus activates the FAK/PI3K/AKT signalling pathway and promotes the invasion and migration of cancer cells (Zheng et al., 2019).