NFKB1 and Hyperglycemia: We often refer to this relationship between glycemic control and the development of organ dysfunction as “blood sugar memory.” Unstable blood glucose can lead to DCM (Pepin and Wende, 2019) due to a combination of the release of ROS from chronic exposure to hyperglycemia (Lebeche, 2015), histone H3K4 methylation, and epigenetic activation of NF-κB-p65 in aortic vascular endothelial cells (El-Osta et al., 2008), and eventually lead to DCM.