Overall, our study confirmed that 1) HECTD2 is up-regulated in RCC and aggravates RCC progression; 2) miR-320a functions as a tumor suppressor in RCC by targeting HECTD2; 3) HIF-1α induces HECTD2 upregulation by repressing miR-320a. The gene discussed is HECTD2; the disease is renal cell carcinoma.