As hypoxia-related transcription factors, HIF-1 and HIF-2 have been confirmed to play a dominant role in transcriptional gene regulation in hypoxia, including miRNAs (Serocki et al., 2018), and this mechanism is also involved in RCC progression (White and Yousef, 2010; Rustum et al., 2018). Here, HIF1A is linked to renal cell adenocarcinoma.