GMPPA and neoplasm: We first examined the distribution of prognostic MSG expression among five immune subtypes reported by a recent study (Thorsson et al., 2018) and found that there was a significant difference in GSS, GMPPA, SGPP2, and PIK3CA among the five immune subtypes (Supplementary Figure S10), suggesting that most prognostic MSGs are closely associated with the tumor immune microenvironment.