Yuan et al. reported that cucurbitacin B (an extract from muskmelon pedicels) could directly bind to Toll-like receptor 4 (TLR4) and activate the NLRP3 inflammasome, which further promoted the production of pore-forming N-terminals of GSDMD to execute pyroptosis in non-small cell lung cancer (Yuan et al., 2021). The gene discussed is TLR4; the disease is non-small cell lung carcinoma.