METTL3 and cardiovascular disorder: In recent years, many studies have revealed the critical roles of m6A methylation in cardiovascular diseases, which were exemplified by abnormal levels of m6A modification as a result of methyltransferases (writer, Mettl3, and Mettl14) and demethylases (eraser, ALKBH5, and FTO) (Qin et al., 2020).