High TGFβ level in patients is associated with poor prognosis (Costa-Silva et al., 2015), however when depleting CAFs, the TME was characterized by decreased angiogenesis, collagen deposition, increased cancer stem cell and regulatory T-cell numbers, and hypoxia, which resulted in worse patient survival (Özdemir et al., 2014). This evidence concerns the gene TGFB1 and cancer.