Many immunosuppressive factors produced by MDSCs, such as TGF-β (Katsuno et al., 2013), VEGF (Oka et al., 2007), IL-10 (Yang et al., 2019), and IL-6 (Kim et al., 2013), have been shown to induce EMT and stemness in various tumor cells. This evidence concerns the gene TGFB1 and neoplasm.