Further studies reported that increased production of IL-10 by MDSCs could inhibit the production of IL-2, IL-12 and IFN-γ by CD4+ or CD8+ T cells, which lead to their impaired proliferation and anti-tumor immunity (Vuk-Pavlovic et al., 2010; Li et al., 2015). The gene discussed is CD8A; the disease is neoplasm.