AKT1 and central nervous system cancer: The PI3K-AKT pathway is a well-known tumor signaling pathway that is involved in the development of various tumors, including glioma (Dai et al., 2017), ovarian cancer (Wu et al., 2021), etc. Moreover, phosphorylation activation of AKT signaling can promote the malignant progression of ovarian cancer (Samartzis et al., 2020; Zhai et al., 2020).