NFKB1 and necrotizing enterocolitis: For example, a combination of B. bifidum and B. longum was found to effectively prevent devastating necrotizing enterocolitis (NEC) in an animal model (Wu et al., 2013); B. adolescentis IM38 ameliorates high fat diet-induced colitis by inhibiting NF-κB activation and lipopolysaccharide production by gut microbiota (Lim and Kim, 2017); B. bifidum ATCC 29521 restores the colon mucus layer of mice with ulcerative colitis by modulating NF-κB signalling pathway and rebuilding the gut intestinal microbiome equilibrium (Din et al., 2020).