ELN and neoplasm: Presented mouse models included the Cdkn2a deficient/ETV6-RUNX1 mouse model, the PAX5-ELN mouse model, and the Sca1-ETV6-RUNX1 mouse model already described in section Experimental Evidence for an Infection-Mediated Childhood Leukemogenesis, Cdkn2a deficient/ETV6-RUNX1 as well as PAX5-ELN transgenic mice developed neoplasms with a high incidence of up to 50-80%, respectively (122, 123).