Recently, it was reported that inactivation of Cdkn2a/p16ink4a gene by CRISPR/Cas9 significantly favored lung metastasis of mouse non-small cell lung carcinoma transplanted subcutaneously and artificial inactivation of CDKN2A gene initiates the invasion of human melanoma cells via BRN2 activation (22, 23). Here, CDKN2A is linked to melanoma.