TDRD3 and USP9X are co-localized together in the structure of cytoplasmic SGs. The presence of TDRD3 is required for USP9X.TDRD3 knockdown enhances apoptosis and makes breast cancer cells more sensitive to camptothecin during the control of USP9X de-ubiquitination activity. This evidence concerns the gene TDRD3 and breast carcinoma.