G3BP1 is overexpressed in gastric cancer, where it represents a significant component of SGs. G3BP1 silencing and cell emptying causes apoptosis and enhances susceptibility to chemotherapy.G3BP1 interacts strongly with YWAHZ, and patients with G3BP1highYWHAZhigh had the poorest outcomes compared to other patients. The gene discussed is G3BP1; the disease is gastric cancer.