ER stress impacts the ARE site in BRCA1 mRNA and can induce down-regulation in BCR-ABL1 leukemia, eventually leading to genomic instability by activating TIAR, which is part of cytoplasmic SGs.Imatinib did not diminish HuR expression and very marginally lowered TIAR expression, but it did reduce HuR binding to BRCA1 mRNA, resulting in BRCA1 mRNA separation from SGs. Here, TIAL1 is linked to leukemia.