PEITC slows mRNA translation via decreasing mTORC1, boosting eIF2α phosphorylation, and promoting the assembly of SGs.PEITC’s chemopreventive and anti-cancer actions are due to its ability to block the mRNA translation pathway.PEITC has the potential to improve the effectiveness of ibrutinib as a chemotherapeutic drug. The gene discussed is EIF2A; the disease is cancer.