We report here a case of high-grade B-cell lymphoma with <i>MYC</i> and <i>BCL6</i> rearrangements relapsing as a high-grade plasmablastic neoplasm with <i>MYC</i> and <i>BCL6</i> rearrangements after R-CHOP and R-EPOCH therapy. Here, DDIT3 is linked to B-cell non-Hodgkin lymphoma.