KRAS and non-small cell lung carcinoma: Other fields of research are exploring new potential indirect targets, for example p65BTK, an isoform of Bruton’s tyrosine kinase expressed in more than 50% NSCLC samples that acts as a downstream effector of RAF/MEK/ERK pathway in KRAS mutated cell lines; this important oncogene, which up to now has been known to be expressed only in hematopoietic cells, could be targetable by BTK inhibitors like ibrutinib (113).