Scientists have already discovered that the ODD region of the HIF-1α protein can directly bind to the DNA-binding region of the p53 protein and may abolish the function of p53, thus hampering gene transactivation in nonmalignant cells (46).However, the accurate binding mechanism between the p53 protein and HIF-1α protein in ovarian cancer is still not clear (Figure 2). The gene discussed is HIF1A; the disease is ovarian carcinoma.