Considering that the Warburg effect plays a large role in promoting cancer progression (63), the inhibition of HIF-1α mediated by miR-519a-5p suppressed the expression of HK2, which plays an important role in the Warburg effect, and this pathway may explain, at least partly, the reason why ginsenoside 20(S)-Rg3 shows antitumoural activity ability in ovarian cancer (107) (Figure 4). Here, HK2 is linked to cancer.