HIF-1α promote the expression of DSCR8, which can sponge miR-98-5p, so that stopping miR-98-5p targeting to the 3’-UTR of STAT3 and then promoting ovarian cancer progression by stimulating the STAT3/HIF-1α pathway, which in turn upregulates DSCR8, creating a positive feedback loop to promote the progression of ovarian cancer (56) (Figure 2). The gene discussed is DSCR8; the disease is ovarian carcinoma.