Adipocytes secrete monocyte chemotactic protein-1 (MCP-1) to bind C-C motif chemokine receptor 2 (CCR-2) on ovarian cancer cells to activate the PI3K/AKT/mTOR pathway, thereby increasing the expression of HIF-1α, which contributes to ovarian cancer metastasis (98). Here, AKT1 is linked to ovarian carcinoma.