Knockdown the HIF-1α expression via siRNA in A2780 and SKOV3 cells significantly downregulated the phosphorylation of AKT/mTOR (58).Besides, AKT pathway regulates the expression of HIF-1α (59, 60) and Herpesvirus entry mediator(HVEM) is overexpressed in ovarian cancer (61). This evidence concerns the gene HIF1A and ovarian carcinoma.