HIF1A and ovarian carcinoma: In late-stage and poorly differentiated ovarian cancer, positive HIF-1α expression is related to a shorter OS time but not a shorter progression-free interval(PFI), while patients who underwent suboptimal cytoreduction and had positive HIF-1α expression exhibited a shorter PFI than HIF-1α-negative patients (29).Only one report found no association between HIF-1α and the overall survival (OS) of ovarian cancer (27).