Ginsenoside 20(S)-Rg3 can facilitate HIF-1α degradation via the activation of the PHD1-VHL-ubiquitin/proteasome pathway, downregulate the expression of E-cadherin, and block the epithelial-mesenchymal transition of ovarian cancer cells in vitro and in vivo (106). The gene discussed is VHL; the disease is ovarian carcinoma.