Because the p53 transcriptional function is eliminated when p53 binds with HIF-1α, the deletion of HIF-1α mediated by TPT can restore the function of p53, downregulate the expression of ABCB5 and ABCB1, modulate the cisplatin and paclitaxel resistance of ovarian cancer and promote apoptosis (45) (Figure 4). Here, HIF1A is linked to ovarian cancer.