TP53 and malignant colon neoplasm: As an important tumour suppressor, p53 plays an important role in modulating drug sensitivity (39–41).After mimicking hypoxic stress, the p53 protein, which is supposed to be induced by doxorubicin or cisplatin, was downregulated so that apoptosis of lung and colon cancer cells mediated through p53 protein was diminished (42).