However, early in 2016, gallic acid, a main polyphenolic compound of C. cathayensis, was shown to upregulate PTEN expression and suppress the phosphorylation of AKT, which led to the downregulation of HIF-1α and VEGF to hamper angiogenesis in ovarian cancer (114) (Figure 4). The gene discussed is VEGFA; the disease is ovarian cancer.