The heatmap reveals that HNRNPLL|53258|AT, CA5B|98313|ES, MEGF6|315|ES, and CDKN2A|86000|AP may have positive effects on lung adenocarcinoma while BEST3|23330|AT, TTC39C|44852|AP, AP2B1|40327|AD, LETM2|83399|AT, and MKL1|62348|AP can have adverse effects (Figure 3F). The gene discussed is LETM2; the disease is lung adenocarcinoma.