All genes in the TRIM family were subjected to the analysis, and then nine genes including TRIM3, TRIM5, MID1, TRIM21, TRIM27, TRIM32, TRIM44, TRIM47, and TRIM72 were identified as genes that might be associated with HCC patients’ OS in both TCGA-LIHC and GSE76427 (p < 0.05, Figures 1B, C). This evidence concerns the gene TRIM21 and hepatocellular carcinoma.