Six genes (TRIM5, MID1, TRIM21, TRIM32, TRIM44, and TRIM47) were prognosis-associated in TCGA-LIHC, while only one gene (TRIM72) was relevant to prognosis in GSE76427 with an HR > 1 among the nine TRIM family members (p < 0.05), which was similar to results of the five reported HCC prognostic biomarkers. Here, TRIM5 is linked to hepatocellular carcinoma.