AR and Familial prostate cancer: Accumulating studies have suggested that the TRIM family proteins play important roles in cell proliferation (9, 10), migration and invasion (9–11), metabolism (12), autophagy, immunity, and carcinogenesis (13), etc. A study in prostate cancer showed that collaborating with the AR signaling, TRIM24 could act as a transcriptional activator of genes involved in the progression of the cell cycle (14).