It was found that eight genes consisting of TRIM3, TRIM5, MID1, TRIM21, TRIM27, TRIM32, TRIM44, and TRIM47 were upregulated in HCC with significant differentiation in TCGA-LIHC and GSE76427 cohorts (p < 0.05, Figures 3A, B). This evidence concerns the gene TRIM21 and hepatocellular carcinoma.