Interestingly, cediranib alone at 500 nM concentration decreased the mRNA level for VEGF-A (p < 0.01, Figure 8D), while pretreatment of A375 melanoma cells with 1,25(OH)2D3 resulted in an increase in the relevant mRNA in melanoma cells incubated subsequently with cediranib at 1,000 nM concentration (p < 0.05). Here, VEGFA is linked to melanoma.