Interestingly, it seems that vitamin D derivatives enhance cediranib efficacy by modulation of VEGFR2 expression in melanoma cells, as we observed a significant increase in VEGFR2 level at both protein and mRNA levels, along with the extracellular VEGFR2 expression, in vitamin D-pretreated A375 melanoma cells incubated further with cediranib. The gene discussed is KDR; the disease is melanoma.