VEGFD and melanoma: mRNA level for VEGF-D was elevated by both 1,25(OH)2D3 and cediranib (p < 0.05, Figure 8F), and it was elevated also in melanoma cells pretreated with vitamin D. Finally, we observed an increase in mRNA level for PDGFRa and PDGFRb in melanoma cells treated with cediranib at 1,000 nM concentration (p < 0.05, Figures 8G, H, respectively); the effect was further exacerbated by vitamin D pretreatment (p < 0.05 for PDGFRa and p < 0.01 for PDGFRb vs. monotreatment).