Similarly, in SK-MEL-28 cells, simultaneous treatment with cediranib and 1,25(OH)2D3 or calcipotriol, at 100 nM concentration, resulted in a further decrease in the proliferation of these melanoma cells, which was accompanied by an increase in the protein level of VEGFR2 compared to control cells in experimental conditions used, although there was no difference in the VEGFR2 protein level compared to monotreatment with cediranib. The gene discussed is KDR; the disease is melanoma.