showed that ZD55 expressing melanoma differentiation-associated gene-7/interleukin-24 (ZD55-IL-24) affects B-lymphoblastic leukemia/lymphoma through upregulation of RNA-dependent protein kinase R, enhance phosphorylation of p38 mitogen-activated protein kinase, and induce of endoplasmic reticulum (ER) stress (99). The gene discussed is IL24; the disease is melanoma.