Among these DEGs, the expression of FAM207A, EXOSC4, ALDH16A1, MZT2B, UBE2S, ACOT2, EPN1, and H2AX was significantly related to WHO grades, while the expression of UBE2S, FAM207A, NT5C, STUB1, MZT2B, SCAND1, EPN1, CTSD, EXOSC4, H2AX, NME3, ALDH16A1, C1orf122, BAD, TIGD5, MAP1S, FAAP20, FZD2, PGLS, and ZNF358 was significantly related to the age of patients with meningioma. The gene discussed is UBE2S; the disease is meningioma.