Multiple recent studies have highlighted diverse miR-148b-3p target genes in a range of human tumor types (24–28), with some prior evidence demonstrating that this miRNA can directly target oncogenes including DNMT3b (25), CCK2R (26), DNMT1 (28), CEA (29), and AMPKα1 (30) in various cancers, thereby functioning as a tumor suppressor. This evidence concerns the gene PRKAA1 and cancer.