PIK3CA and adenocarcinoma: Other examples of carcinogenic drivers for adenocarcinoma include modifications in protein kinase B (AKT), BRAF, human epidermal growth factor receptor-2 (HER2), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), MET, ROS1, RET, and KRAS [15].