CD8A and Autoimmunity: Following the electroporation of mRNA encoding peptide/ β2 microglobulin (β2m)/CD3-ζ, Fishman et al. demonstrated that CD8 T-cells can be reprogrammed to identify diabetogenic T-cells and that this might target autoreactive CD4 and CD8 T-cells (CTLs) in vivo to reduce insulitis and alleviate autoimmunity in the NOD mouse.